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  • 焼酎学コース
  • 国立大学法人鹿児島大学
  • 鹿児島大学大学院連合農学研究科

    • Ⅰ．受賞

    • 2013年　　　環境バイオテクノロジー学会 奨励賞
      　　　　　　「海洋堆積物における脱ハロゲン呼吸細菌の分布」
    • 2016年　　　日本農芸化学会西日本支部 支部奨励賞（一般）
      　　　　　　「Aspergillus属糸状菌のストレス応答に関する研究」
    • 2020年　　　糸状菌遺伝子研究会 奨励賞
      　　　　　　「白麹菌のクエン酸高生産機構に関する研究」
    • 2021年　　　日本農芸化学会 農芸化学奨励賞
      　　　　　　「白麹菌のクエン酸高生産機構に関する研究」

    Ⅱ．科学研究費

    https://kaken.nii.ac.jp/ja/search/?qm=60512027

    Ⅲ．学術論文

    • Kadooka C, Nakamura E, Kubo S, Okutsu K, Yoshizaki Y, Takamine K, Tamaki H, Futagami T. (2020) Analysis of the fungal population involved in Katsuobushi production. J. Gen. Appl. Microbiol. doi: 10.2323/jgam.2019.09.003.
    • Kadooka C, Nakamura E, Mori K, Okutsu K, Yoshizaki Y, Takamine K, Goto M, Tamaki H, Futagami T. (2020) LaeA controls citric acid production through regulation of the citrate exporter-encoding cexA gene in Aspergillus luchuensis mut. kawachii. Appl. Environ. Microbiol. 86, e01950-19.
    • Miyamoto A, Kadooka C, Mori K, Tagawa Y, Okutsu K, Yoshizaki Y, Takamine K, Goto M, Tamaki H, Futagami T. (2020) Sirtuin SirD is involved in α-amylase activity and citric acid production in Aspergillus luchuensis mut. kawachii during a solid-state fermentation process. J. Biosci. Bioeng. 129, 454-466.
    • Yin X, Yoshizaki Y, Ikenaga M, Han XL, Okutsu K, Futagami T, Tamaki H, Takamine K. (2020) Manufactural impact of the solid-state saccharification process in rice-flavor baijiu production. J. Biosci. Bioeng. 129, 315-321.
    • 瀬戸口翔, 益留綾菜, 大岩達郎, 二神泰基, 河野邦晃, 岩井謙一, 玉置尚徳. 酸性プロテアーゼを高生産する黒麹菌の育種と芋焼酎醸造試験. 日本醸造学会誌. 115, 54-61. 2020.
    • 瀬戸口翔, 章超, 飯島遼平, 二神泰基, 河野邦晃, 岩井謙一, 玉置尚徳. 焼酎醸造において発酵遅延を引き起こす黄変黒麹から見出された抗菌物質の抗菌効果. 日本醸造学会誌. 115, 151-158. 2020.
    • Hirose J, Fujihara H, Watanabe T, Kimura N, Suenaga H, Futagami T, Goto M, Suyama A, Furukawa K. (2019) Biphenyl/PCB degrading bph genes of ten bacterial strains isolated from biphenyl-contaminated soil in Kitakyushu, Japan: comparative and dynamic features as integrative conjugative elements (ICEs). Genes (Basel). 10, E404.
    • Kurokawa Y, Konishi R, Yoshida A, Tomioku K, Futagami T, Tamaki H, Tanabe K, Fujita A. (2019) Essential and distinct roles of phosphatidylinositol 4-kinases, Pik1p and Stt4p, in yeast autophagy. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids. 1864, 1214-1225.
    • Setoguchi S, Mizutani O, Yamada O, Futagami T, Iwai K, Takase Y, Tamaki H. (2019) Effect of pepA deletion and overexpression in Aspergillus luchuensis on sweet potato shochu brewing. J. Biosci. Bioeng. 128, 456-462.
    • Kadooka C, Izumitsu K, Onoue M, Okutsu K, Yoshizaki Y, Takamine K, Goto M, Tamaki H, Futagami T. (2019) Mitochondrial citrate transporters CtpA and YhmA are required for extracellular citric acid accumulation and contribute to cytosolic acetyl-CoA generation in Aspergillus luchuensis mut. kawachii. Appl. Environ. Microbiol. 85, AEM.03136-18.
    • Kojo T, Kawai M, Shiraishi Y, Kurazono S, Kadooka C, Okutsu K, Yoshizaki Y, Ikenaga M, Futagami T, Takamine K, Tamaki H. (2019) Effect of maturation time on koji-like smell and volatile compounds of barley miso (Japanese soybean paste) during fermentation. Food Sci. Technol. Res. 25, 313-319.
    • Sobol MS, Hoshino T, Futagami T, Inagaki F, Kiel Reese B. (2019) Draft genome sequences of Penicillium spp. from deeply buried oligotrophic marine sediments. Microbiol Resour. Announc. 8, e01613-18.
    • Kimoto D, Kadooka C, Saenrungrot P, Okutsu K, Yoshizaki Y, Takamine K, Goto M, Tamaki H, Futagami T. (2019) Pex16 is involved in peroxisome and Woronin body formation in the white koji fungus, Aspergillus luchuensis mut. kawachii. J. Biosci. Bioeng. 127, 85-92.
    • 中川智行, 内田みなみ, 平井菜未, 奥村真衣, 吉村明浩, 澤井美伯, 正木和夫, 二神泰基, 玉置尚徳, 向田潤, 三井亮司, 稲垣瑞穂, 島田昌也, 鈴木徹, 杉山誠, 早川享志. (2019) 新奇清酒酵母の開発に向けた岐阜県自然環境からの出芽酵母のスクリーニングとその清酒醸造特性. 日本醸造協会誌. 114, 43-52.
    • 白石洋平, 原口愛美, 村田梨恵, 久遼馬, 奥津果優, 吉﨑由美子, 二神泰基, 玉置尚徳, 和久豊, 髙峯和則. (2018) 異なる黒麴菌を用いた本格焼酎の酒質の多様化. 日本醸造協会誌. 113, 757-765.
    • 髙峯和則, 小島舞, 奥津果優, 二神泰基, 玉置尚徳, 吉﨑由美子. (2018) 芋焼酎の発酵および酒質に及ぼす二次醪pHの影響. 日本醸造協会誌. 113, 375-382.
    • 吉﨑由美子, 奥津果優, 二神泰基, 玉置尚徳, 鮫島吉廣, 髙峯和則. (2018) プロテアーゼまたは細胞壁分解酵素製剤添加による紅麹焼酎製造法の改良. 日本醸造協会誌. 113, 265-272.
    • Wakamatsu T, Morono Y, Futagami T, Terada T, Nishikawa S, Morisawa T, Ohshita K, Inagaki F, Ashiuchi M. (2018) Metal-ion-induced expression of gene fragments from subseafloor micro-organisms in the Kumano forearc basin, Nankai Trough. J. Appl. Microbiol. 125, 1396-1407.
    • Tomioku KN, Shigekuni M, Hayashi H, Yoshida A, Futagami T, Tamaki H, Tanabe K, Fujita A. (2018) Nanoscale domain formation of phosphatidylinositol 4-phosphate in the plasma and vacuolar membranes of living yeast cells. Eur. J. Cell Biol. 97, 269-278.
    • Kimura N, Watanabe T, Suenaga H, Fujihara H, Futagami T, Goto M, Hanada S, Hirose J. (2018) Pseudomonas furukawaii sp. nov., a polychlorinated biphenyldegrading bacterium isolated from biphenyl-contaminated soil in Japan. Int. J. Syst. Evol. Microbiol. 68, 1429-1435.
    • Kojo T, Kadooka C, Komohara M, Onitsuka S, Tanimura M, Muroi Y, Kurazono S, Shiraishi Y, Oda K, Iwashita K, Onoue M, Okutsu K, Yoshizaki Y, Takamine K, Futagami T, Mori K, Tamaki H. (2018) Characterization of amylolytic enzyme overproducing mutant of Aspergillus luchuensis obtained by ion beam mutagenesis. J. Gen. Appl. Microbiol. 63, 339-346.
    • Futagami T, Kadooka C, Ando Y, Okutsu K, Yoshizaki Y, Setoguchi S, Takamine K, Kawai M, Tamaki H. (2017) Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster. Yeast. 34, 407-415.
    • Suenaga H, Fujihara H, Kimura N, Hirose J, Watanabe T, Futagami T, Goto M, Shimodaira J, Furukawa K. (2017) Insights into the genomic plasticity of Pseudomonas putida KF715, a strain with unique biphenyl-utilizing activity and genome instability properties. Environ Microbiol Rep. 9, 589-598.
    • 白石洋平, 安藤有加, 奥津果優, 吉﨑由美子, 二神泰基, 玉置尚徳, 和久豊, 髙峯和則. (2017) 芋焼酎醪へのプロテアーゼ剤添加による揮発成分と官能評価への影響. 日本醸造協会誌、112, 517-523.
    • 白石洋平, 安藤有加, 奥津果優, 吉﨑由美子, 二神泰基, 玉置尚徳, 和久豊, 髙峯和則. (2017) 芋焼酎の香気成分に及ぼすアミノ酸の影響. 日本醸造協会誌、112，563-568.
    • 奥津果優, 門岡千尋, 小城章裕, 吉﨑由美子, 二神泰基, 玉置尚徳, 髙峯和則. (2017) 中国及び韓国の市場品「神麹」における菌叢と含有成分の実態調査. 生薬学雑誌 71, 41-48.
    • Suenaga H, Yamazoe A, Hosoyama A, Kimura N, Hirose J, Watanabe T, Fujihara H, Futagami T, Goto M, Furukawa K. (2017) Complete genome sequence of the polychlorinated biphenyl-degrading bacterium Pseudomonas putida KF715 (NBRC 110667) isolated from biphenyl-contaminated soil. Genome Announc. 5, e01624-16.
    • Rahayu YY, Yoshizaki Y, Yamaguchi K, Okutsu K, Futagami T, Tamaki H, Sameshima Y, Takamine K. (2017) Key volatile compounds in red koji-shochu, a Monascus-fermented product, and their formation steps during fermentation. Food Chemistry. 224, 398-406.
    • Yamada O, Machida M, Hosoyama A, Goto M, Takahashi T, Futagami T, Yamagata Y, Takeuchi M, Kobayashi T, Koike H, Abe K, Asai K, Arita M, Fujita N, Fukuda K, Higa KI, Horikawa H, Ishikawa T, Jinno K, Kato Y, Kirimura K, Mizutani O, Nakasone K, Sano M, Shiraishi Y, Tsukahara M, Gomi K. (2016) Genome sequence of Aspergillus luchuensis NBRC 4314. DNA Res. 23, 507-515.
    • Shiraishi Y, Yoshizaki Y, Ono T, Yamato H, Okutsu K, Tamaki H, Futagami T, Sameshima Y, Takamine K. (2016) Characteristic odour compounds in shochu derived from rice koji. Journal of the Institute of Brewing. 122, 381-387.
    • Kadooka C, Onitsuka S, Uzawa M, Tashiro S, Kajiwara Y, Takashita H, Okutsu K, Yoshizaki Y, Takamine K, Goto M, Tamaki H, Futagami T. (2016) Marker recycling system using the sC gene in the white koji mold, Aspergillus luchuensis mut. kawachii. J. Gen. Appl. Microbiol. 62, 160-163.
    • Futagami T, Mori K, Wada S, Ida H, Kajiwara Y, Takashita H, Tashiro K, Yamada O, Omori T, Kuhara S, Goto M. (2015) Transcriptomic analysis of temperature responses of Aspergillus kawachii during barley koji production. Appl. Environ. Microbiol. 81, 1353-1363.
    • Hirose J, Yamazoe A, Hosoyama A, Kimura N, Suenaga H, Watanabe T, Fujihara H, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of the polychlorinated biphenyl degrading bacterium Pseudomonas stutzeri KF716 (NBRC 110668). Genome Announc. 3, e01215-15.
    • Hirose J, Yamazoe A, Hosoyama A, Kimura N, Suenaga H, Watanabe T, Fujihara H, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of the polychlorinated biphenyl-degrading bacterium Comamonas testosteroni KF712 (NBRC110673). Genome Announc. 3, e01214-15.
    • Fujihara H, Yamazoe A, Hosoyama A, Suenaga H, Kimura N, Hirose J, Watanabe T, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of Pseudomonas aeruginosa KF702 (NBRC 110665), a polychlorinated biphenyl-degrading bacterium isolated from biphenyl-contaminated soil. Genome Announc. 3, e00517-15.
    • Fujihara H, Yamazoe A, Hosoyama A, Suenaga H, Kimura N, Hirose J, Watanabe T, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of Pseudomonas abietaniphila KF701 (NBRC110664), a polychlorinated biphenyl-degrading bacterium isolated from biphenyl-contaminated soil. Genome Announc. 3, e00473-15.
    • Watanabe T, Yamazoe A, Hosoyama A, Fujihara H, Suenaga H, Hirose J, Futagami T, Goto M, Kimura N, Furukawa K. (2015) Draft genome sequence of Cupriavidus pauculus strain KF709, a biphenyl-utilizing bacterium isolated from biphenyl-contaminated soil. Genome Announc. 3, e00222-15.
    • Suenaga H, Yamazoe A, Hosoyama A, Kimura N, Hirose J, Watanabe T, Fujihara H, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of the polychlorinated biphenyl-degrading bacterium Cupriavidus basilensis KF708 (NBRC 110671) isolated from biphenyl-contaminated Soil. Genome Announc. 3, e00143-15.
    • Suenaga H, Yamazoe A, Hosoyama A, Kimura N, Hirose J, Watanabe T, Fujihara H, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of the polychlorinated biphenyl-degrading bacterium Pseudomonas putida KF703 (NBRC 110666) isolated from biphenyl-contaminated soil. Genome Announc. 3, e00142-15.
    • Kimura N, Yamazoe A, Hosoyama A, Hirose J, Watanabe T, Suenaga H, Fujihara H, Futagami T, Goto M, Furukawa K. (2015) Draft genome sequence of Pseudomonas abietaniphila KF717 (NBRC 110669), isolated from biphenyl-contaminated soil in Japan. Genome Announc. 3, e00059-15.
    • Futagami T, Seto K, Kajiwara Y, Takashita H, Omori T, Takegawa K, Goto M. (2014) The putative stress sensor protein MtlA is required for conidia formation, cell wall stress tolerance, and cell wall integrity in Aspergillus nidulans. Biosci. Biotechnol. Biochem. 78, 326-335.
    • Kawai M, Futagami T, Toyoda A, Takaki Y, Nishi S, Hori S, Arai W, Tsubouchi T, Morono Y, Uchiyama I, Itoh T, Fujiyama A, Inagaki F, Takami H. (2014) High frequency of phylogenetically diverse reductive dehalogenase-homologous genes in deep subseafloor sedimentary metagenomes. Front. Microbiol. 5, 80.
    • Oba Y, Futaghami T, Amachi S. (2014) Enrichment of a microbial consortium capable of reductive deiodination of 2,4,6-triiodophenol. J. Biosci. Bioeng. 117, 310-317.
    • Komachi Y, Hatakeyama S, Motomatsu H, Futagami T, Kinzjakina K, Sorbado P, Ekino K, Takegawa K, Goto M, Nomura Y, Oka T. (2013) gfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O-glycan in Aspergillus nidulans and A. fumigatus. Mol. Microbiol. 90, 1054-1073.
    • Tashiro S, Futagami T, Wada S, Kajiwara Y, Takashita H, Omori T, Takahashi T, Yamada O, Takegawa K, and Goto M. (2013) Construction of a ligD disruptant for efficient gene targeting in white koji mold, Aspergillus kawachii. J. Gen. Appl. Microbiol. 59, 257-260.
    • Futagami T, Fukaki Y, Fujihara H, Takegawa K, Goto M, Furukawa K. (2013) Evaluation of the inhibitory effects of chloroform on ortho-chlorophenol- and chloroethene-dechlorinating Desulfitobacterium strains. AMB Express. 3, 30.
    • Futagami T, Morono Y, Terada T, Kaksonen A H, Inagaki F. (2013) Distribution of dehalogenation activity in subseafloor sediments of the Nankai Trough subduction zone. Phil. Trans. R. Soc. B. 368, 20120249.
    • Futagami T, Goto M. (2012) Putative cell wall integrity sensor proteins in Aspergillus nidulans. Commun. Integr. Biol. 5, 206-208.
    • Yanagawa K, Morono Y, de Beer D, Haeckel M, Sunamura M, Futagami T, Hoshino T, Terada T, Nakamura K, Urabe T, Rehder G, Boetius A, Inagaki F. (2012) Metabolically active microbial communities in marine sediment under high-CO2 and low-pH extremes. ISME J. 7, 555-567.
    • Briggs BR, Inagaki F, Morono Y, Futagami T, Huguet C, Rosell-Mele A, Lorenson TD, Colwell FS. (2012) Bacterial dominance in subseafloor sediments characterized by methane hydrates. FEMS Microbiol. Ecol. 81, 88-98.
    • Futagami T, Mori K, Yamashita A, Wada S, Kajiwara Y, Takashita H, Omori T, Takegawa K, Tashiro K, Kuhara S, Goto M. (2011) Genome sequence of the white Koji mold Aspergillus kawachii IFO 4308 used for brewing the Japanese distilled spirit Shochu. Eukaryot. Cell. 10, 1586-1587.
    • Futagami T, Nakao S, Kido Y, Oka T, Kajiwara Y, Takashita H, Omori T, Furukawa K, Goto M. (2011) Putative stress sensors WscA and WscB are involved in hypo-osmotic and acidic pH stress tolerance in Aspergillus nidulans. Eukaryot. Cell. 10, 1504-1515.
    • Futagami T, Okamoto F, Hashimoto H, Fukuzawa K, Higashi K, Nazir KH, Wada E, Suyama A, Takegawa K, Goto M, Nakamura K, Furukawa K. (2011) Enrichment and characterization of a trichloroethene-dechlorinating consortium containing multiple “Dehalococcoides” strains. Biosci. Biotechnol. Biochem. 75, 1268-1274.
    • Mitsuiki S, Takasugi M, Moriyama Y, Futagami T, Goto M, Kanouchi H, Oka T. (2010) Identification of an alkaliphilic actinomycetes that produces a PrPSc-degrading enzyme. Ann. Microbiol. 60, 349-353.
    • Futagami T, Morono Y, Terada T, Kaksonen AH, Inagaki F. (2009) Dehalogenation activities and distribution of reductive dehalogenase homologous genes in marine subsurface sediments. Appl. Environ. Microbiol. 75, 6905-6909.
    • Morita Y, Futagami T, Goto M, Furukawa K. (2009) Functional characterization of the trigger factor protein PceT of tetrachloroethene-dechlorinating Desulfitobacterium hafniense Y51. Appl. Microbiol. Biotechnol. 83, 775-781.
    • Futagami T, Yamaguchi T, Nakayama S, Goto M, Furukawa K. (2006) Effects of chloromethanes on growth of and deletion of the pce gene cluster in dehalorespiring Desulfitobacterium hafniensestrainY51. Appl. Environ. Microbiol. 72, 5998-6003.
    • Futagami T, Tsuboi Y, Suyama A, Goto M, Furukawa K. (2006) Emergence of two types of nondechlorinating variants in the tetrachloroethene-halorespiring Desulfitobacterium sp. strain Y51. Appl. Microbiol. Biotechnol. 70, 720-728.
    • Iwakiri R, Yoshihira K, Ngadiman, Futagami T, Goto M, Furukawa K. (2004) Total degradation of pentachloroethane by an engineered Alcaligenes strain expressing a modified camphor monooxygenase and a hybrid dioxygenase. Biosci. Biotechnol. Biochem. 68, 1353-1356.
    • Suyama A, Futagami T, Takeshita M, Goto M, Furukawa K. (2004) Molecular breeding of various bph-tod hybrid strains for efficient degradation of trichloroethene. Journal of Environmental Biotechnology. 3, 95-100.

    Ⅳ．著書・解説・総説

    • 二神泰基, 門岡千尋. 焼酎造りに用いられる白麹菌のクエン酸高生産機構. バイオサイエンスとインダストリー. 78, 213-216, 2020.
    • 二神泰基, 玉置尚徳, 後藤正利, 髙峯和則. 焼酎学へのいざない. 生物工学会誌. 97, 82-86. 2019.
    • 二神泰基. 焼酎. In: 北本勝ひこ、春田伸、丸山潤一、後藤慶一、尾花望、斉藤勝晴　編、食と微生物の事典. 朝倉書店. pp. 16-17, 2017.
    • 二神泰基, 後藤正利. 焼酎製造に用いられる白麹菌のゲノム解析と育種基盤の開発. バイオサイエンスとインダストリー. 74, 402-205, 2016.
    • Futagami T, Furukawa K. The Genus Desulfitobacterium. In: Adrian L, Löffler FE (eds), Organohalide-Respiring Bacteria. Springer Berlin Heidelberg, pp. 173-207, 2016.
    • Oka T, Futagami T, Goto M. Cell wall biosynthesis in filamentous fungi. In: Takagi H, Kitagaki H (eds), Stress Biology of Yeasts and Fungi. Springer Japan, pp. 151-168, 2015.
    • 二神泰基. 本格焼酎と微生物の関わり. 生物工学会誌. 92, 678. 2014.
    • 後藤正利, 二神泰基, 梶原康博, 高下秀春. 焼酎麹菌のIdentityを探る. 日本醸造協会誌. 109, 219-227, 2014.
    • Futagami T, Goto M, Furukawa K. Genetic system of organohalide-respiring bacteria. In: Nojiri H, Tsuda M, Fukuda M, and Kamagata Y (eds), Biodegradative Bacteria. Springer Verlag, Tokyo. pp. 59-81, 2014.
    • 二神泰基, 諸野祐樹, 稲垣史生. 海洋環境における脱ハロゲン呼吸細菌. 環境バイオテクノロジー学会誌. 13, 117-123, 2013.
    • 二神泰基. 環境汚染が促す微生物進化. 生物工学会誌. 87, 238, 2009.
    • Futagami T, Goto M, Furukawa K. Biochemical and genetic bases of dehalorespiration. Chem. Rec. 8, 1-12, 2008.
    • 二神泰基, 古川謙介. 微生物による環境汚染有機塩素化合物の分解. 排水・汚水処理技術集成. エヌティエス出版. 第1編 第2章 第7節. 2007.
    • 二神泰基, 後藤正利, 古川謙介. 脱ハロゲン呼吸細菌の還元的デハロゲナーゼ. 環境バイオテクノロジー学会誌. 7, 107-110, 2007.
    • 後藤正利, 二神泰基, 藤原秀彦, 古川謙介. 難分解性化学物質の微生物による分解・無毒化技術. 各種手法による有機物の分解技術.（株）技術情報社. 第2章 第4節. 2007
    • 二神泰基, 後藤正利, 古川謙介. クロロエテン脱ハロゲン呼吸細菌の遺伝生化学と機能進化. タンパク質核酸酵素. 共立出版. 50, 1548-1554, 2005.
    • Furukawa K, Suyama A, Tsuboi Y, Futagami T, Goto M. Biochemical and molecular characterization of a tetrachloroethene dechlorinating Desulfitobacterium sp. strain Y51: a review. J. Ind. Microbiol. Biotechnol. 32, 534-541, 2005.